Imaging Biotin Trafficking In Vivo with Positron Emission Tomography
Salvatore Bongarzone, Teresa Sementa, Joel Dunn, Jayanta Bordoloi, Kavitha Sunassee, Philip J. Blower, Antony D. Gee
Abstract
C]Biotin PET imaging therefore provides a dynamic in vivo map of transporter-mediated biotin trafficking in healthy rodents. This technique will enable the exploration of biotin trafficking in humans and its use as a research tool for diagnostic imaging of obesity/diabetes, bacterial infection, and cancer.
Topics & Concepts
BiotinIn vivoPositron emission tomographyAvidinChemistryExcretionPreclinical imagingBiochemistryMedicineBiologyNuclear medicineBiotechnologyBiotin and Related StudiesAdipose Tissue and MetabolismRetinoids in leukemia and cellular processes