Recent Advances in the Synthesis of Acyl Fluorides
Marie Gonay, Chloé Batisse, Jean‐François Paquin
Abstract
Abstract Acyl fluorides are valuable intermediates in organic synthesis. They are increasingly employed in peptide synthesis, in challenging esterification and amidation reactions or in transition-metal-catalyzed transformations. This review summarizes recent advances in their preparation. 1 Introduction 2 Nucleophilic Fluorination 2.1 α-Fluoroamine Reagents 2.2 Sulfur-Based Reagents 2.3 Metal Catalysts 2.4 Phosphorus-Based Reagents 2.5 N,N′-Dicyclohexylcarbodiimide/HF·Pyridine 2.6 Uranium Hexafluoride 2.7 Bromine Trifluoride 3 Radical Fluorination 4 Conclusion
Topics & Concepts
ChemistryReagentNucleophileCatalysisBromineOrganic chemistryPyridineOrganic synthesisCombinatorial chemistrySulfurPhosphorusFluorine in Organic ChemistryChemical Synthesis and AnalysisSulfur-Based Synthesis Techniques