Developmental changes in lung function of mice are independent of sex as a biological variable
Thomas Bärnthaler, Abhay B. Ramachandra, Sadè Ebanks, Nicole Guerrera, Lokesh Sharma, Charles S. Dela Cruz, Jay D. Humphrey, Edward P. Manning
2024American Journal of Physiology-Lung Cellular and Molecular Physiology10 citationsDOIOpen Access PDF
Abstract
This study provides reference values for changes in mouse lung biomechanics from 2 to 23 wk of age. There are rapid developmental changes in lung structure and function of male and female mice between the ages of 3 and 8 wk. Male mice become noticeably heavier than female mice at or about 5 wk of age. We identified that differences in normal lung function measurements are likely weight-based, not sex-based.
Topics & Concepts
Lung functionVariable (mathematics)Function (biology)BiologyPhysiologyLungMedicineInternal medicineEvolutionary biologyMathematicsMathematical analysisAsthma and respiratory diseasesNeonatal Respiratory Health ResearchPulmonary Hypertension Research and Treatments