Lipid-injured hepatocytes release sOPN to improve macrophage migration via CD44 engagement and pFak-NFκB signaling
Xin Jiang, Fan Zhang, Xueying Ji, Fangyuan Dong, Huiyuan Yu, Mengjuan Xue, Yixuan Qiu, Fan Yang, Xiaona Hu, Zhijun Bao
Topics & Concepts
HepatocyteLipotoxicityMacrophageInflammationCell biologyHepatic stellate cellBiologyOsteopontinDownregulation and upregulationCell migrationChemistryCellEndocrinologyImmunologyIn vitroBiochemistryInsulin resistanceInsulinGeneBone and Dental Protein StudiesLiver Disease Diagnosis and TreatmentBone Metabolism and Diseases