Room-Temperature Cu(II) Radical-Triggered Alkyne C–H Activation
Jack Devonport, Lauren Sully, A.K. Boudalis, Storm Hassell‐Hart, Matthew C. Leech, Kevin Lam, Alaa Abdul‐Sada, Graham J. Tizzard, Simon J. Coles, John Spencer, Alfredo Vargas, George E. Κostakis
Abstract
) intermediate. This unusual C-H activation method is applicable for the efficient synthesis of propargylamines, without additives, within 16 h, at low loadings and in noncoordinating solvents including late-stage functionalization of important bioactive molecules. Single-crystal X-ray diffraction studies, postcatalysis, confirmed the framework's stability and showed that the metal center preserves its oxidation state. The scope and limitations of this unconventional protocol are discussed.
Topics & Concepts
ChemistryElectron paramagnetic resonanceAlkyneDichloromethaneCyclic voltammetryCrystallographyLigand (biochemistry)RedoxMonomerPhotochemistryMedicinal chemistryPolymer chemistryStereochemistryInorganic chemistrySolventElectrochemistryPhysical chemistryOrganic chemistryCatalysisPhysicsElectrodeReceptorPolymerBiochemistryNuclear magnetic resonanceCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsRadical Photochemical Reactions