ROS-targeting heterojunction-integrated GelMA microneedles for photo-responsive antioxidative action and accelerated diabetic wound healing
Jinlan Tang, Weijun Liu, Zhengyao Zhang, Yang Ye, Wenwen Cheng, Xiaoyu Wang, Zesheng Chen, Zijian Wang, Weikang Hu
Abstract
The ACMGM microneedle system effectively delivers nanozymes through the skin and enhances their catalytic activity upon exposure to visible light. This precisely modulates the oxidative stress microenvironment in refractory wounds, offering an innovative therapeutic strategy for diabetic wound treatment.
Topics & Concepts
Oxidative stressReactive oxygen speciesChemistryBiocompatibilitySuperoxide dismutaseWound healingAntioxidantRegeneration (biology)Self-healing hydrogelsCatalasePharmacologyInflammationPhotocatalysisTransdermalBiomedical engineeringNanotechnologyControlled releaseCatalysisSensitizationDiabetes mellitusOxidative phosphorylationOxidative damageCell damageAdvancements in Transdermal Drug DeliveryVagus Nerve Stimulation ResearchSpectroscopy Techniques in Biomedical and Chemical Research