Scar prevention through topical delivery of gelatin-tyramine-siSPARC nanoplex loaded in dissolvable hyaluronic acid microneedle patch across skin barrier
Yong Yao Chun, Wei Tan, Marcus Ivan Gerard Vos, Wen Kiat Chan, Hong Liang Tey, Nguan Soon Tan, Timothy Thatt Yang Tan
Abstract
< 0.05) and do not cause discernable cytotoxic effects. Further studies using a mouse wound model demonstrate that the siSPARC/Gtn-Tyr-loaded microneedle patch can reduce collagen production during wound healing without triggering an immune response. When Gtn-Tyr-siSPARC is administered transdermally at the wound site, effective collagen reduction is achieved through silencing of the matricellular SPARC protein, thus promising the reduction of scar formation. Overall, the siSPARC/Gtn-Tyr loaded microneedle patch can potentially provide an effective transdermal anti-fibrotic treatment.
Topics & Concepts
Hyaluronic acidGelatinWound healingDermal fibroblastTransdermalChemistryPharmacologyFibrosisScarsFibroblastIn vitroMedicinePathologyBiochemistryImmunologyAnatomyDermatologic Treatments and ResearchWound Healing and TreatmentsLaser Applications in Dentistry and Medicine