Catalytic asymmetric synthesis of 3,4′-indole–pyrazole derivatives featuring axially chiral bis-pentatomic heteroaryls
Chenghao Li, Wei‐Fang Zuo, Jin Zhou, Wu-Jingyun Zhou, Meng Wang, Xiang Li, Gu Zhan, Wei Huang
Abstract
We reported the catalytic asymmetric construction of the axially chiral 3,4′-indole–pyrazole skeleton, a bis-pentatomic heteroaryl scaffold in many bioactive molecules.
Topics & Concepts
ChemistryPyrazoleIndole testAxial symmetryCatalysisCombinatorial chemistryMoleculeEnantioselective synthesisStereochemistryOrganic chemistryStructural engineeringEngineeringAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAlgebraic structures and combinatorial models