Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly Correlated
Alexander Seupt, Monika Schniederjans, Jürgen Tomasch, Susanne Häußler
Abstract
The impact of MexXY efflux pump expression on aminoglycoside resistance in clinical Pseudomonas aeruginosa isolates has been debated. In this study, we found that, in general, elevated mexXY gene expression levels in clinical P. aeruginosa isolates confer to slight increases in aminoglycoside MIC levels; however, those levels rarely lead to clinically relevant resistance phenotypes. The main driver of resistance in the clinical isolates studied here was the acquisition of aminoglycoside-modifying enzymes (AMEs).
Topics & Concepts
AminoglycosidePseudomonas aeruginosaEffluxMicrobiologyBiologyPseudomonadaceaeAntibioticsBacteriaGeneticsAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingAntibiotics Pharmacokinetics and Efficacy