Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells
Vanessa Pereira de Souza, Fabiano da Silveira Santos, Fabiano Severo Rodembusch, Carolyne B. Braga, Cátia Ornelas, Ronaldo A. Pilli, Dennis Russowsky
Abstract
A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative, were designed and synthesized with good yields.
Topics & Concepts
ChemistryFluorescenceCytotoxic T cellDerivative (finance)Combinatorial chemistryDual (grammatical number)MoleculeBiginelli reactionBiochemistryOrganic chemistryIn vitroCatalysisLiteraturePhysicsFinancial economicsEconomicsArtQuantum mechanicsBioactive Compounds and Antitumor AgentsMulticomponent Synthesis of HeterocyclesSynthesis and biological activity