Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure–Activity Relationship Insights and Evolution Perspectives
Gabriele La Monica, Alessia Bono, Antonino Lauria, Annamaria Martorana
Abstract
inhibitors.
Topics & Concepts
ChemistryIn silicoCovalent bondProteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Computational biologyElectrophileStructure–activity relationshipCoronavirus disease 2019 (COVID-19)In vivoEnzymeCombinatorial chemistryIn vitroBiochemistryStereochemistryBiologyCatalysisOrganic chemistryGeneGeneticsMedicineInfectious disease (medical specialty)PathologyDiseaseComputational Drug Discovery MethodsClick Chemistry and ApplicationsSynthesis and biological activity