Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy
Enhui Song, Qiong Wu, Ren Gao, Xiaopeng Lan, Yanhui Zhang, Hao Geng, Chunlei Liu, Chunlei Liu, Feijie Xu, Yongxin Li, Chunzhao Liu, Chunzhao Liu
Abstract
to produce hydroxyl radicals (˙OH), and ˙OH-triggered rapid release of dual parent drugs were specifically activated in tumor cells. With these cascade reactions, the catalytic-chemo synergetic therapy was realized for high-efficiency tumor suppression.
Topics & Concepts
Supramolecular chemistryNanomedicineCombinatorial chemistryCatalysisGlucose oxidaseProdrugCascade reactionRadicalChemistryDoxorubicinAmphiphileMaterials scienceNanotechnologyOrganic chemistryBiochemistryNanoparticleBiosensorPolymerChemotherapyMoleculeMedicineSurgeryCopolymerNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanocluster Synthesis and Applications