Ginsenoside CK ameliorates hepatic lipid accumulation <i>via</i> activating the LKB1/AMPK pathway <i>in vitro</i> and <i>in vivo</i>
Jingjing Zhang, Xiaoxuan Ma, Daidi Fan
Abstract
activating the phosphorylation of LKB1 and AMPK. Compound C, an inhibitor of AMPK, partially abrogated the beneficial effects of ginsenoside CK in HepG2 cells. In summary, ginsenoside CK acts as a LKB1/AMPK agonist to regulate the lipid metabolism and interfere with the progression of NAFLD.
Topics & Concepts
AMPKSteatosisLipid metabolismNonalcoholic fatty liver diseaseFatty liverInternal medicineEndocrinologyIn vivoOil Red OLipid dropletHepatic stellate cellChemistryPharmacologyAdipose tissueBiologyMedicineBiochemistryKinaseProtein kinase AAdipogenesisBiotechnologyDiseaseLiver Disease Diagnosis and TreatmentGinseng Biological Effects and ApplicationsMetabolism, Diabetes, and Cancer