Synthetic Route to Enaminones via Metal-Free Four-Component Sequential Reactions of Aryl Olefins with CHCl<sub>3</sub>, Et<sub>3</sub>N, and TBHP
Jiantao Zhang, Peng Zhou, Aiguo Yin, Shu‐Hua Zhang, Weibing Liu
Abstract
An efficient and modular strategy was used to obtain enaminones with a wide range of functional groups via a four-component sequential reaction. This reaction proceeded under mild conditions without a catalyst in one pot. Furthermore, the products could be transformed into thiadiazoles.
Topics & Concepts
Component (thermodynamics)CatalysisModular designArylChemistryCombinatorial chemistryRange (aeronautics)Reaction conditionsThiadiazolesOrganic chemistryComputer scienceMaterials sciencePhysicsThermodynamicsOperating systemComposite materialAlkylSynthesis and Characterization of PyrrolesMulticomponent Synthesis of HeterocyclesCatalytic C–H Functionalization Methods