PMN-MDSCs accumulation induced by CXCL1 promotes CD8+ T cells exhaustion in gastric cancer
Xingyu Zhou, Deliang Fang, Haohan Liu, Xinde Ou, Chaoyue Zhang, Zirui Zhao, Shaoji Zhao, Jianjun Peng, Shirong Cai, Yulong He, Jianbo Xu
Topics & Concepts
CXCL1Cancer researchMyeloid-derived Suppressor CellTLR4CD8Downregulation and upregulationS100A8ImmunologyChemokineImmune systemChemistryInflammationCancerMedicineSuppressorInternal medicineGeneBiochemistryImmune cells in cancerCancer Immunotherapy and BiomarkersChemokine receptors and signaling