An ionizable lipid toolbox for RNA delivery
Xuexiang Han, Hanwen Zhang, Kamila Butowska, Kelsey L. Swingle, Mohamad‐Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Abstract
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
Topics & Concepts
RNAChemistryRNA world hypothesisComponent (thermodynamics)NanotechnologyKey (lock)BiochemistryBiologyMaterials sciencePhysicsRibozymeEcologyGeneThermodynamicsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms