β-Cyclodextrin-Stabilized Biosynthesis Nanozyme for Dual Enzyme Mimicking and Fenton Reaction with a High Potential Anticancer Agent
Salim Ali, Suranjan Sikdar, Shatarupa Basak, Biplab Rajbanshi, Modhusudan Mondal, Debadrita Roy, Ankita Dutta, Anoop Kumar, Vikas Kumar Dakua, Rinku Chakrabarty, A.C. Roy, Abhinath Barman, Anupam Datta, Pijush Kanti Roy, Bhaskar Chakraborty, Mahendra Nath Roy
Abstract
nanoparticles. Inspired by the high ROS generation in vitro method, we investigated the disruption of human kidney cells by this nanoparticle, successfully verified by the MTT assay. The harmful effect of ROS in a normal cell is also investigated by the in vitro MTT assay. The results suggested that the appreciable anticancer activity with minimal side effects by this synthesized nanomaterial.
Topics & Concepts
Reactive oxygen speciesChemistryPeroxidaseOxidative stressCatalysisCeriumEnzymeNADPH oxidaseCancer therapyRedoxCombinatorial chemistryCyclodextrinBiochemistryCancerOrganic chemistryBiologyGeneticsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsNanocluster Synthesis and Applications