6″-Modifed α-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria
Michael A. Meijlink, Yu Cheng Chua, Susanna T. S. Chan, R. J. Anderson, Matthew W. Rosenberg, Anton Cozijnsen, Vanessa Mollard, Geoffrey I. McFadden, Sarah L. Draper, Lauren E. Holz, Ian F. Hermans, William R. Heath, Gavin F. Painter, Benjamin J. Compton
Abstract
responses in mice. Our findings demonstrate that attaching antigenic peptides to 6″-modifed α-GalCer generates powerful self-adjuvanting conjugate vaccine candidates that could potentially control hepatotropic infections such as liver-stage malaria.
Topics & Concepts
Plasmodium bergheiAdjuvantConjugateEpitopeAntigenPeptideImmune systemPeptide vaccineConjugate vaccineBiologyChemistryVirologyImmunologyBiochemistryImmunogenicityMalariaMathematical analysisMathematicsvaccines and immunoinformatics approachesMalaria Research and ControlImmunotherapy and Immune Responses