A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics
Ayad A. Al-Hamashi, Radhika Koranne, Samkeliso Dlamini, Abdulateef Alqahtani, Endri Karaj, Maisha S. Rashid, Joseph R. Knoff, Matthew Dunworth, Mary Kay H. Pflum, Robert A. Casero, L. Perera, William R. Taylor, L. M. Viranga Tillekeratne
Topics & Concepts
TubulinChemistryMitosisMicrotubule polymerizationMicrotubuleMechanism of actionDocking (animal)BiochemistryCytotoxicityCancer cellNocodazoleChalconeCell biologyIn vitroStereochemistryCellBiologyCytoskeletonCancerNursingGeneticsMedicineHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCancer Mechanisms and Therapy