Egg-yolk core–shell mesoporous silica nanoparticles for high doxorubicin loading and delivery to prostate cancer cells
Steffi Tiburcius, Kannan Krishnan, Linta Jose, Vaishwik Patel, Arnab Ghosh, CI Sathish, Judith Weidenhofer, Jae‐Hun Yang, Nicole Beydon, Ajay Karakoti, Ajayan Vinu
Abstract
for MSN samples due to the uniform distribution of nitrogen functionalities. The anticancer activity of Dox loaded MSNs evaluated in two different prostate cancer cell lines (PC-3 and LNCaP) showed a higher cytotoxicity of the drug loaded on optimised MSN samples as compared to pristine MSNs without affecting the cellular uptake of the particles. These results suggest that the unique single-step synthesis and functionalisation method resulted in successfully achieving higher drug loading in egg-yolk core-shell nitrogen functionalised MSNs and could be implemented as an effective carrier of chemotherapeutic drugs.