Medullary Carcinoma of the Colon: A Histopathologic Challenge
Zainab Fatima, Purva Sharma, Bahaaeldin Youssef, Koyamangalath Krishnan
Abstract
Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge.
Topics & Concepts
MedicineColorectal cancerMedullary cavityAdenocarcinomaPathologyMedullary carcinomaImmunohistochemistryPresentation (obstetrics)CarcinomaColon carcinomaGeneral surgeryCancerInternal medicineRadiologyThyroid carcinomaThyroidGenetic factors in colorectal cancerColorectal Cancer Treatments and StudiesColorectal Cancer Screening and Detection