Intestinal Microbiota in Sepsis
Tongwen Sun, Le‐Xin Wang, Haibo Zhang
Abstract
Abstract Sepsis is defined as a life-threatening organ dysfunction, which is caused by a dysregulated host response to infection. The composition of the intestinal microbiota is significantly different between patients with sepsis and healthy individuals. Intestinal microbial imbalance plays an important role in the occurrence and development of sepsis. Our review mainly introduces the mechanism of intestinal microbiota involvement in sepsis, the effects of microbiota dysbiosis on the damage of multiple organs and concisely discusses the prospects for microbe-specific treatment of sepsis in the future.
Topics & Concepts
SepsisDysbiosisImmunologyGut floraOrgan dysfunctionMechanism (biology)MedicineBiologyIntensive care medicineEpistemologyPhilosophyGut microbiota and healthClostridium difficile and Clostridium perfringens researchGastrointestinal motility and disorders