Nickel‐Catalyzed Cross‐Electrophile Coupling of Aryl Phosphates with Aryl Bromides
Jing‐Ao Ren, Xue Chen, Chao Gui, Chengping Miao, Xue‐Qiang Chu, Hao Xu, Xiaocong Zhou, Mengtao Ma, Zhi‐Liang Shen
Abstract
Abstract A step‐economical and operationally simple nickel‐catalyzed cross‐electrophile coupling of aryl phosphates with aryl bromides through C−O bond cleavage, which precluded the employment of relatively moisture‐labile and unreadily available organometallics, was developed. The reaction proceeded smoothly in the presence of magnesium turnings and lithium chloride in THF to afford the corresponding biaryls in moderate to good yields with reasonable functionality tolerance.
Topics & Concepts
ArylChemistryElectrophileNickelCatalysisMagnesiumCleavage (geology)ChlorideBond cleavageLithium (medication)Lithium chlorideMedicinal chemistryOrganic chemistryCombinatorial chemistryAlkylGeotechnical engineeringMedicineEngineeringFracture (geology)EndocrinologyCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques