Streamlined Carbonylation of Csp<sup>3</sup>–H Bonds: Divergent Synthesis of Diverse Carbonyl Compounds
Le‐Cheng Wang, Hefei Yang, Qiangwei Li, Xiao‐Feng Wu
Abstract
High Resolution Image Download MS PowerPoint Slide Transition metal-catalyzed carbonylation reactions present a promising strategy for synthesizing valuable carbonyl-containing compounds. However, a significant limitation is the need for stepwise optimization of reaction conditions for different carbonyl types due to the inherent reactivity differences among coupling partners. In this context, we introduce a general photochemical strategy that facilitates the efficient synthesis of a diverse range of carbonyl compounds. This approach minimizes the need for extensive optimization by maintaining consistent reaction conditions, effectively addressing the challenges posed by varying reactivity and providing a versatile tool for organic synthesis. Moreover, this mild and practical method establishes a distinctive approach for obtaining valuable carbonyl compounds from abundant and low-cost starting materials while showcasing its flexibility with various coupling partners. By leveraging readily available aliphatic C–H bonds, this protocol offers a complementary approach to traditional Csp 3 –H carbonylation, positioning it as a crucial asset in the research toolkit for carbonyl synthesis.