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Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential

Mengze Zhou, Weiwei Wang, Zhongkui Wang, Yilin Wang, Yifan Zhu, Zhiqian Lin, Sheng Tian, Yuan Huang, Qinghua Hu, Huanqiu Li

2021European Journal of Medicinal Chemistry20 citationsDOIOpen Access PDF

Topics & Concepts

BenzoxazoleChemistryAcetamideIn vivoPharmacologyGoutAntagonistLead compoundIC50Virtual screeningArthritisDocking (animal)Ex vivoReceptorStereochemistryIn vitroBiochemistryDrug discoveryMedicineInternal medicineBiotechnologyBiologyOrganic chemistryNursingAdenosine and Purinergic SignalingUrticaria and Related ConditionsNeuropeptides and Animal Physiology
Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential | Litcius