Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation
Valérie Vanhoorne, Ruben Almey, Thomas De Beer, Chris Vervaet
Topics & Concepts
MannitolGranulationTabletingExcipientGranule (geology)PolyvinylpyrrolidoneBreakageMaterials scienceSpray dryingChromatographyDosage formChemical engineeringChemistryComposite materialPolymer chemistryOrganic chemistryEngineeringDrug Solubulity and Delivery SystemsProtein purification and stabilityAdvanced Drug Delivery Systems