Cryptococcus neoformans<i>-</i>Infected Macrophages Release Proinflammatory Extracellular Vesicles: Insight into Their Components by Multi-omics
Lei Zhang, Keming Zhang, Hang Li, Carolina Coelho, Diego de Souza Gonçalves, Man Shun Fu, Xinhua Li, Ernesto Nakayasu, Young‐Mo Kim, Wanqing Liao, Weihua Pan, Arturo Casadevall
Abstract
-infected macrophage vesicles also showed higher fungicidal biological effects on inactivated macrophages. Using omics technology, unique protein and lipid signatures were identified in these extracellular vesicles. Transcriptome analysis showed that these vesicles activated immune-related pathways like p53 in naive macrophages. The understanding of this intermacrophage communication could provide potential targets for the design of therapeutic agents to fight this deadly mycosis.
Topics & Concepts
Cryptococcus neoformansProinflammatory cytokineExtracellular vesiclesExtracellularMicrobiologyBiologyChemistryCell biologyImmunologyInflammationFungal Infections and StudiesStreptococcal Infections and TreatmentsInflammasome and immune disorders