Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens
Lukas Pinkert, Yi-Hui Lai, Carsten Peukert, Sven‐Kevin Hotop, Bianka Karge, Lara Marie Schulze, Jörg Grunenberg, Mark Brönstrup
Abstract
was mediated by a mutation in the gene encoding ExbB, which is involved in siderophore transport.
Topics & Concepts
SiderophoreEscherichia coliChemistryMicrobiologyIn silicoDaptomycinBacteriaAntibioticsGram-negative bacteriaBacterial outer membraneAntimicrobialLinkerMutantAntibiotic resistanceConjugateGram-positive bacteriaBiochemistryBiologyGeneStaphylococcus aureusOperating systemMathematicsComputer scienceMathematical analysisGeneticsVancomycinAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyCancer therapeutics and mechanisms