EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer
Huilong Yin, Yidi Wang, Ye Wu, Xiang Zhang, Xiaofang Zhang, Jun Liu, Ting Wang, Jing Fan, Jianyong Sun, Angang Yang, Rui Zhang
Abstract
Our findings identified EZH2-miR-29b/miR-30d-LOXL4 signaling pathway was involved in breast tumorigenesis, and suggested that the epigenetic modulation represents a potential therapeutic target for breast cancer by controlling macrophage activation.
Topics & Concepts
Cancer researchCarcinogenesisMetastasisEZH2BiologyBreast cancerTumor progressionmicroRNAGene silencingTumor microenvironmentEpigeneticsCancerGeneticsTumor cellsGeneBiochemistryCancer-related molecular mechanisms researchRNA modifications and cancerFerroptosis and cancer prognosis