Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme–substrate binding
Deliang Chen, Yibao Li, Xun Li, Xuechuan Hong, Xiaolin Fan, Tor Savidge
Abstract
and the mechanism of enhancing atomic charge densities. Our findings may help resolve the debate between TS stabilization and GS destabilization and assist our understanding of catalysis and the design of artificial enzymes.
Topics & Concepts
Key (lock)Substrate (aquarium)Charge (physics)Ground stateTransition (genetics)Chemical physicsState (computer science)Transition metalChemistryAtomic physicsMaterials scienceNanotechnologyPhysicsComputer scienceBiochemistryQuantum mechanicsBiologyCatalysisEcologyGeneComputer securityAlgorithmEnzyme Structure and FunctionAmino Acid Enzymes and MetabolismProtein Structure and Dynamics