TRIM4 enhances small-molecule-induced neddylated-degradation of CORO1A for triple negative breast cancer therapy
Wenjie Gu, Xiaoxia Liu, Yiwen Shen, Yi-Ting Gong, Yili Chen, Jiayi Lin, Dong Lu, Li-Jun Zhang, Hongzhuan Chen, Yi Jin, Zha‐Jun Zhan, Weidong Zhang, Jinmei Jin, Xin Luan
Abstract
Our findings underscore the critical role of CORO1A in TNBC and lay a crucial foundation for the development of innovative drugs based on molecular glue technology.
Topics & Concepts
Triple-negative breast cancerBreast cancerCancerCancer researchDegradation (telecommunications)MedicineOncologyChemistryInternal medicineComputer scienceTelecommunicationsinterferon and immune responsesPeptidase Inhibition and AnalysisGalectins and Cancer Biology