The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution
Daniele Focosi, Pietro Giorgio Spezia, Federico Gueli, Fabrizio Maggi
Abstract
Convergent evolution of the SARS-CoV-2 Spike protein has been mostly driven by immune escape, in particular by escape to the viral infection-neutralizing antibodies (nAbs) elicited by previous infections and/or vaccinations [...].
Topics & Concepts
Spike (software development)Spike ProteinSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune escapeVirologyCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakBiologyAntibodyImmune systemViral evolutionMutationVaccinationGeneticsMedicineGeneGenomeOutbreakInfectious disease (medical specialty)EconomicsDiseasePathologyManagementSARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesViral Infections and Outbreaks Research