Regulation of Deubiquitinating Enzymes by Post-Translational Modifications
Tanuza Das, Sang Chul Shin, Eun Joo Song, Eunice EunKyeong Kim
Abstract
Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes, and the enzymes involved are tightly regulated by multiple factors including posttranslational modifications like most other proteins. Dysfunction or misregulation of these enzymes could have dramatic physiological consequences, sometimes leading to diseases. Therefore, it is important to have a clear understanding of these regulatory processes. Here, we have reviewed the posttranslational modifications of deubiquitinating enzymes and their consequences on the catalytic activity, stability, abundance, localization, and interaction with the partner proteins.
Topics & Concepts
Deubiquitinating enzymeUbiquitinEnzymePosttranslational modificationPost-translational regulationSUMO enzymesUbiquitinsCell biologyBiologyBiochemistryChemistrySUMO proteinUbiquitin ligasePhosphorylationGeneUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors