AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice
Jiaming Wang, Yue Zhang, Craig A. Mendonca, Onur Yukselen, Khaja Muneeruddin, Lingzhi Ren, Jialing Liang, Chen Zhou, Jun Xie, Jia Li, Zhong Jiang, Alper Küçükural, Scott A. Shaffer, Guangping Gao, Dan Wang
Topics & Concepts
Nonsense mutationBiologyGenetic enhancementAdeno-associated virusStop codonGeneTransfer RNATransgeneMutationGeneticsRNARecombinant DNAVector (molecular biology)Missense mutationRNA Interference and Gene DeliveryVirus-based gene therapy researchRNA and protein synthesis mechanisms