Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization
Erica A. Moehle, Ryo Higuchi‐Sanabria, C. Kimberly Tsui, Stefan Homentcovschi, Kevin M. Tharp, Hanlin Zhang, Hannah Chi, Larry Joe, Mattias de los Rios Rogers, Arushi Sahay, Naame Kelet, Camila Benitez, Raz Bar‐Ziv, Gilberto Garcia, Koning Shen, Phillip A. Frankino, Robert T. Schinzel, Ophir Shalem, Andrew Dillin
Abstract
regulation through integrin-mediated remodeling of the actin cytoskeleton. This study also highlights the use of cross-species comparisons in genetic screens to interrogate cellular pathways.
Topics & Concepts
ActinLink (geometry)MitochondrionMitochondrial DNACell biologyBiologyComputational biologyGeneticsComputer scienceGeneComputer networkMitochondrial Function and PathologyATP Synthase and ATPases ResearchGenetics, Aging, and Longevity in Model Organisms