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Adaptive and context-aware volumetric printing

Sammy Florczak, Gabriel Größbacher, Davide Ribezzi, Alessia Longoni, Marième Gueye, Estée Grandidier, Jos Malda, Riccardo Levato

2025Nature28 citationsDOIOpen Access PDF

Abstract

Abstract We introduce Generative, Adaptive, Context-Aware 3D Printing (GRACE), a new approach combining 3D imaging, computer vision and parametric modelling to create tailored, context-aware geometries using volumetric additive manufacturing. GRACE rapidly and automatically generates complex structures capable of conforming directly around features ranging from cellular to macroscopic scales with minimal user intervention. Here we demonstrate its versatility in applications ranging from synthetic objects to biofabrication, including adaptive vascular-like geometries around cell-laden bioinks, resulting in improved functionality. GRACE also enables precise alignment of sequential prints, as well as the detection and overprinting of opaque surfaces through shadow correction. Compatible with various printing modalities 1–4 , GRACE transcends traditional additive manufacturing limitations in automating overprinting and adapting the printed designs to the content of the printable material. This opens new possibilities in tissue engineering and regenerative medicine.

Topics & Concepts

BiofabricationOverprinting3D printingComputer scienceContext (archaeology)RangingRegenerative medicineParametric statisticsArtificial intelligenceModalitiesComputer graphics (images)Computer visionEngineering drawingNanotechnologyTissue engineeringMaterials scienceMechanical engineeringBiomedical engineeringEngineeringPaleontologyMathematicsGeochemistrySocial scienceStem cellGeologyGeneticsStatisticsMetamorphic rockTelecommunicationsBiologySociology3D Printing in Biomedical ResearchAdditive Manufacturing and 3D Printing TechnologiesAnatomy and Medical Technology
Adaptive and context-aware volumetric printing | Litcius