Ruthenium(<scp>ii</scp>)–arene complexes as anti-metastatic agents, and related techniques
Chanchal Sonkar, Sayantan Sarkar, Suman Mukhopadhyay
Abstract
NAMI-A, KP1019, KP1339, and TLD1433, have entered clinical trials. Some other arene ruthenium complexes such as RM175 and RAPTA-C have also entered clinical trials but very few of them have shown anti-metastatic properties. Herein, we provide information and probable mechanistic pathways for ruthenium(ii)-arene complexes that have been studied, so far, for their anti-metastatic activities. Also, we discuss the techniques and their significance for determining the anti-metastatic effects of the complexes.
Topics & Concepts
RutheniumChemistryCombinatorial chemistryStereochemistryCancer researchBiochemistryMedicineCatalysisMetal complexes synthesis and propertiesRadiopharmaceutical Chemistry and ApplicationsLanthanide and Transition Metal Complexes