Correlation between the IgG/IgA Antibody Response against PEDV Structural Protein and Virus Neutralization
Xu Song, Jiali Qian, Chuanhong Wang, Dandan Wang, Junming Zhou, Yongxiang Zhao, Wei Wang, Jizong Li, Rongli Guo, Yunchuan Li, Xuejiao Zhu, Shanshan Yang, Xuehan Zhang, Baochao Fan, Bin Li
Abstract
The humoral immune response plays an important role in virus neutralization. Against PEDV, both IgG and the mucosal immune component IgA play roles in virus neutralization. However, which plays a more prominent role and whether there are differences in different tissue samples are not clearly reported. Additionally, the relationship between IgG and IgA against individual structural proteins and viral neutralization remains unclear. In this study, we systematically determined the relationship between IgG and IgA against all PEDV structural proteins and viral neutralization in different clinical samples and found the highest correlation between neutralization activity and IgA to PEDV S1 protein. Our data have important guiding implications in the evaluation of immune protection.