Comparison of pharmacokinetics, biodistribution, and excretion of free and bound Nε-carboxymethyllysine in rats by HPLC–MS/MS
Xiaojin Yuan, Ruohan Zhai, Yanan Bai, Min Zheng, Xiaoqing Xie, Tao Chen, Ting Huang, Zhifei Chen, Juxiu Li
Topics & Concepts
PharmacokineticsChemistryBioavailabilityBiodistributionExcretionVolume of distributionIn vivoUrinePharmacologyFree fractionOral administrationHigh-performance liquid chromatographyChromatographyDistribution (mathematics)BiochemistryIn vitroMedicineBiologyMathematicsBiotechnologyMathematical analysisAdvanced Glycation End Products researchAlcohol Consumption and Health EffectsNatural Antidiabetic Agents Studies