Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Taisuke Kondo, François X. P. Bourassa, Sooraj Achar, Justyn DuSold, Pablo F. Céspedes, Makoto Ando, Alka Dwivedi, Josquin Moraly, Christopher D. Chien, Saliha Majdoul, Adam L Kenet, Madison Wahlsten, Audun Kvalvaag, Edward Jenkins, Sanghyun P. Kim, Catherine M. Ade, Zhiya Yu, Guillaume Gaud, Marco L. Davila, Paul E. Love, James Chih‐Hsin Yang, Michael L. Dustin, Grégoire Altan-Bonnet, Paul François, Naomi Taylor
Topics & Concepts
T-cell receptorChimeric antigen receptorBiologyAntigenCancer immunotherapyImmunotherapyCancer researchCrosstalkT cellReceptorTumor microenvironmentCell biologyImmunologyImmune systemTumor cellsBiochemistryOpticsPhysicsCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsNanowire Synthesis and Applications