Less is more: Self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells
Helena Vanluchene, Oriane Gillon, Karen Peynshaert, Stefaan C. De Smedt, Niek N. Sanders, Koen Raemdonck, Katrien Remaut
Topics & Concepts
Immune systemInnate immune systemBiologyRetinalImmunogenicityMessenger RNATransfectionCell biologyMolecular biologyImmunologyCell cultureGeneticsBiochemistryGeneRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research