Current Techniques and Indications for Machine Perfusion and Regional Perfusion in Deceased Donor Liver Transplantation
Christopher J.E. Watson, Rohit Gaurav, Andrew J. Butler
Abstract
The landscape of liver transplantation is changing, and the opportunities offered by machine perfusion are set to make more of the currently available organs fit for transplantation, as well as making more organs available. Technology is in its infancy at present, and will improve over the next decade. While some livers are unlikely to benefit significantly, such as those from young fit donors implanted with minimal ischaemia, it is likely that machine perfusion will become commonly applied either in the form of NRP at retrieval for DCD livers, or ESMP post extraction for DBD and DCD livers. There is also the opportunity of combining technologies to allow their individual strengths to work synergistically. This is commonly done for DCD donation in Italy where the mandated long asystolic time results in significantly compromised livers.140De Carlis L. De Carlis R. Lauterio A. Di Sandro S. Ferla F. Zanierato M. Sequential use of normothermic regional perfusion and hypothermic machine perfusion in donation after cardiac death liver transplantation with extended warm ischemia time.Letter. Transplantation. 2016; 100: e101-e102https://doi.org/10.1097/TP.0000000000001419Crossref PubMed Scopus (37) Google Scholar