NHC‐Activations on α‐, β‐, γ‐, and Beyond
Xiaoyu Chen, Pengyu He, Siqi Xia, Lixin Cui, Guofu Zhong, Limin Yang
Abstract
Over the recent decades, due to the special electronic characteristics and diverse reactivities, N-heterocyclic carbene (NHC) has received significant interest in organocatalyzed reactions. The formation of Breslow intermediates by NHC can convert into acyl anion equivalent, enolates, homoenolate, acyl azolium, and vinyl enolate etc., and the cycloaddition reactions of these species has attracted lots of attention. In this review, we focus on the summry of the development of NHC-activation of carbonyl carbon (or imine carbon) in situ, α-, β-, γ-, and beyond, and the cycloaddition reaction of these species.
Topics & Concepts
CarbeneCycloadditionImineChemistryCarbon fibersIonCombinatorial chemistryCatalysisOrganic chemistryPhotochemistryMaterials scienceComposite numberComposite materialN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods