Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition
Min Yan, Jing Hu, Huating Yuan, Liwen Xu, Gaoming Liao, Z. X. Jiang, Jiali Zhu, Bo Pang, Yanyan Ping, Yunpeng Zhang, Yun Xiao, Xia Li
Abstract
was associated with the clinical outcome of tumor patients. Our study embedded transcription factors (TFs) within the temporal dynamic networks, providing a comprehensive view of dynamic regulatory mechanisms controlling the process of T cell state transition.
Topics & Concepts
TranscriptomeGene regulatory networkTransition (genetics)CellBiologyTranscription factorTranscriptional regulationComputational biologyT cellRegulation of gene expressionGeneImmune systemGeneticsGene expressionSingle-cell and spatial transcriptomicsT-cell and B-cell ImmunologyImmune Cell Function and Interaction