Select hyperactivating NLRP3 ligands enhance the T <sub>H</sub> 1- and T <sub>H</sub> 17-inducing potential of human type 2 conventional dendritic cells
Lukas Hatscher, Christian H.K. Lehmann, Ariawan Purbojo, Constantin Onderka, Chunguang Liang, Arndt Hartmann, Robert Cesnjevar, Heiko Bruns, Olaf Groß, Falk Nimmerjahn, Ivana Ivanović‐Burmazović, Meik Kunz, Lukas Heger, Diana Dudziak
Abstract
17 responses that were superior to those seen in response to Toll-like receptor (TLR) stimulation alone or to stronger, classical inflammasome ligands. These findings not only define the human cDC2 subpopulation as a prime target for the treatment of inflammasome-dependent inflammatory diseases but may also inform new approaches for adjuvant and vaccine development.
Topics & Concepts
PyroptosisInflammasomeCell biologyImmune systemBiologyDendritic cellSecretionReceptorImmunologyCytokinePattern recognition receptorInflammationInnate immune systemBiochemistryInflammasome and immune disordersImmune Response and InflammationImmunotherapy and Immune Responses