Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation
Gailutė Drakšienė, Brigita Venclovaitė, Lauryna Pudžiuvelytė, Людас Іванаускас, Mindaugas Marksa, Jurga Bernatonienė
Abstract
The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets.
Topics & Concepts
MeloxicamGranulationChitosanBiopolymerDissolutionChemistryMaterials scienceChromatographyPolymerPharmacologyComposite materialMedicineOrganic chemistryDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAnalytical Methods in Pharmaceuticals