Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis
Jaqueline S. Generoso, Sigrun Thorsdottir, Allan Collodel, Diogo Dominguini, Roberta R. E. Santo, Fabrícia Petronilho, Tatiana Barichello, Federico Iovino
Abstract
The lack of solute drainage due to a dysfunctional glymphatic system leads to an increase of the neurotoxic bacterial material in the CSF compartments of the brain, ultimately leading to brain-wide neuroinflammation and neuronal damage with consequent impairment of neurological functions. The loss of function of the glymphatic system can therefore be a leading cause of the neurological sequelae developing post-bacterial meningitis.
Topics & Concepts
Glymphatic systemMeningesMeningitisStreptococcus pneumoniaeCerebrospinal fluidAquaporin 4MedicineParenchymaImmunologyBlood–brain barrierCentral nervous systemPathologyMicrobiologyBiologyInternal medicineAntibioticsSurgeryCerebrospinal fluid and hydrocephalusNeuroscience of respiration and sleepFetal and Pediatric Neurological Disorders