Electrochemically enabled dearomative [2 + 2] cycloadditions of indoles with alkynes to access cyclobutene-fused indolines
Jingjing Zi, Huiling Tang, Dongyin Wang, Meng Li, Yuxiang Zhou, Sihui Lv, Deqiang Liang, Lou Shi
Abstract
A novel regioselective electrochemical [2 + 2] cyclization of N -acyl indoles with alkynes to provide cyclobutene-fused indolines under mild conditions with high regioisomeric ratios was developed.
Topics & Concepts
CyclobuteneChemistryCombinatorial chemistryOrganic chemistryRing (chemistry)Oxidative Organic Chemistry ReactionsRadical Photochemical ReactionsCatalytic C–H Functionalization Methods