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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

GCKD Investigators, Pascal Schlosser, Yong Li, Peggy Sekula, Johannes Raffler, Franziska Grundner-Culemann, Maik Pietzner, Yurong Cheng, Matthias Wuttke, Inga Steinbrenner, Ulla T. Schultheiß, Fruzsina Kotsis, Tim Kacprowski, Lukas Forer, Birgit Hausknecht, Arif B. Ekici, Matthias Nauck, Uwe Völker, Gerd Walz, Peter J. Oefner, Florian Kronenberg, Robert P. Mohney, Michael Köttgen, Karsten Suhre, Kai‐Uwe Eckardt, Gabi Kastenmüller, Anna Köttgen

2020Nature Genetics148 citationsDOIOpen Access PDF

Topics & Concepts

BiologyADMEGenome-wide association studyComputational biologyMetaboliteGeneticsMetabolomicsGeneBiobankGenomeQuantitative trait locusLocus (genetics)Single-nucleotide polymorphismBioinformaticsGenotypeBiochemistryIn vitroGenetic Associations and EpidemiologyBirth, Development, and HealthGenetic Syndromes and Imprinting
Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans | Litcius