Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects
Cara Nelson, Kim Etchevers, Saili Yi, David G. Breckenridge, Mischa Hepner, Uptal D. Patel, John Ling, Anita Mathias
Topics & Concepts
PharmacokineticsTolerabilityPharmacologyApoptosisKinaseASK1MedicineChemistryProtein kinase AAdverse effectCyclin-dependent kinase 2BiochemistryRedox biology and oxidative stressCell death mechanisms and regulationSulfur Compounds in Biology